【論文】

 1.   Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells.

Shoji E., Sakurai H., Nishino T., Nakahata T., Heike T., Awaya T., Fujii N., Manabe Y., Matsuo M., Sehara-Fujisawa A.
Scientific Reports. 2015 :5, Article number: 12831; doi:10.1038/srep12831

 2.    Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9.
Li HL., Fujimoto N., Sasakawa N., Shirai S., Ohkame T., Sakuma T., Tanaka M., Amano N., Watanabe A., Sakurai H., Yamamoto T., Yamanaka S., Hotta A.
Stem Cell Reports. 2015 Jan 13;4(1):143-54.

 3.   Functional analysis of iPSC-derived myocytes from a patient with carnitine palmitoyltransferase II deficiency.
Yasuno T., Osafune K., Sakurai H., Asaka I., Tanaka A., Yamaguchi S., Yamada K., Hitomi H., Arai S., Kurose Y., Higaki Y., Sudo M., Ando S., Nakashima H., Saito T., Kaneoka H.
Biochem Biophys Res Commun. 2014 May 30;448(2):175-81.

 4.   In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells.
Noguchi M., Hosoda K., Nakane M., Mori E., Nakao K., Taura D., Yamamoto Y., Kusakabe T., Sone M., Sakurai H., Fujikura J., Ebihara K., Nakao K.
Stem Cells Dev. 2013 Nov 1;22(21):2895-905.

 5.   Fetal skeletal muscle progenitors have regenerative capacity after intramuscular engraftment in dystrophin deficient mice.
Sakai H., Sato T., Sakurai H., Yamamoto T., Hanaoka K., Montarras D., Sehara-Fujisawa A.
PLoS One. 2013 May 9;8(5):e63016

 6.   Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Myoshi Myopathy in vitro6.
Tanaka A, Woltjen K, Miyake K, Hotta A, Ikeya M, Yamamoto T, Nishino T, Shoji E, Sehara-Fujisawa A, Manabe Y, Fujii N, Hanaoka K, Era T, Yamashita S, Isobe K, Kimura E, Sakurai H.
PLoS One. 2013, 8(4):e61540

 7.   In Vitro Modeling of Paraxial Mesodermal Progenitors Derived from Induced Pluripotent Stem
Sakurai H., Sakaguchi Y., Shoji E., Nishino T., Maki I., Sakai H., Hanaoka K., Kakizuka A., Sehara-Fujisawa A.
PLoS ONE. 2012,7(10): e47078.

 8.   Differentiation of induced pluripotent stem cells to thymic epithelial cells by phenotype
Inami Y., Yoshikai T., Ito S., Nishio N., Suzuki H., Sakurai H., Isobe K.
Immunology and Cell Biology. 2011, 89, 314-21.

 9.   GADD34 suppresses wound healing by upregulating expression of myosin IIA.
Tanaka C, Ito S, Nishio N, Kodera Y, Sakurai H, Suzuki H, Nakao A, Isobe K.
Transgenic Res. 2010 Aug;19(4):637-45.

 10.   Metalloprotease-Dependent Onset of Blood Circulation in Zebrafish.
Iida A., Sakaguchi K., Sato K., Sakurai H., Nishimura D., Iwaki A., Takeuchi M., Kobayashi M., Misaki K., Yonemura S., Kawahara A., Sehara-Fujisawa A.
Current Biology. 2010 June; 20(12): 1110-16.

 11.   Bidirectional induction toward paraxial mesodermal derivatives from mouse ES cells in chemically defined medium
Sakurai H., Inami Y., Tamamura Y., Yoshikai T., Sehara-Fujisawa A., Isobe K.
Stem Cell Research. 2009 Sep-Nov;(2-3): 157-69.

 12.   Paraxial mesodermal progenitors derived from mouse embryonic stem cells contribute to muscle regeneration via differentiation into muscle satellite cells
Sakurai H., Okawa Y., Inami Y., Nishio N., Isobe K.
Stem Cells. 2008 Jul;26(7): 1865-73

 13.   Neutrophil depletion delays wound repair in aged mice
Nishio N., Okawa Y., Sakurai H., Isobe K.
Age. 2008; 30: 11-19

 14.   In vitro modeling of paraxial and lateral mesoderm differentiation reveals early reversibility
Sakurai H., Era T., Lakt LM., Okada M., Nakai S., Nishikawa S., Nishikawa SI.
Stem Cells. 2006 Mar;24(3): 575-86

 15.   Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture
Tada S., Era T., Furusawa C., Sakurai H., Nishikawa S., Kinoshita M., Chiba T., Nishikawa SI
Development. 2005 Oct;132(19): 4363-74

【プロトコール】

1. Directed Myogenic Differentiation of Human Induced Pluripotent Stem Cells.
Shoji E, Woltjen K, Sakurai H.
Methods in Mol Biol. 2015 May 14.

2. ヒトiPS細胞から骨格筋細胞への効率的な分化誘導
庄子栄美、櫻井英俊
ES・iPS細胞実験スタンダード(羊土社) 2014:194-201

【日本語解説】

1. iPS細胞を使った筋疾患研究
櫻井英俊
病理と臨床 2015:33(6): 592-598

2. 患者由来iPS細胞による筋疾患モデル作製
櫻井英俊
医学のあゆみ 2015:252(9): 969-975

3. 三好型ミオパチー
櫻井英俊
遺伝子医学MOOK 2015:“27 iPS細胞を用いた難病研究”: 71-76

4. iPS細胞を用いた難治性筋疾患治療研究
櫻井英俊
実験医学2014:32(9):1359-1365

5. iPS細胞創薬は10年以内に実現するか?「Yes」の立場から
櫻井英俊
Frontiers in Parkinson Disease 2014:7(4):200-203

6. iPS細胞を用いた筋疾患モデル
櫻井英俊
最新医学 2014:69: 589-597

7. iPS細胞技術を用いた筋再生療法の開発
櫻井英俊
整形・災害外科 2013:56(5):689-694

8. iPS細胞を用いた筋ジストロフィー症の病態解析
竹中菜々、櫻井英俊
Medical Science Digest 2013:39(11): 514-517

9. iPS細胞を使う―骨格筋の研究へ―
竹中菜々、櫻井英俊
整形外科 2013:64(11): 1221-1223

10. iPS細胞
櫻井英俊、山中伸弥
先進医療 NAVIGATOR 2013: 93-95

11. 多能性幹細胞による筋ジストロフィー治療
櫻井英俊
生体の科学(医学書院)  2011:62(2): 161-164

12. iPS細胞(人工多能性幹細胞)研究
櫻井英俊、山中伸弥
日本臨床 2011:69(12): 2114-18